Therapeutic Action of Different Penicillins on Spirochaetal Infections
نویسندگان
چکیده
منابع مشابه
Antagonism of the antibacterial action of some penicillins by other penicillins and cephalosporins.
There are many examples of two penicillins acting synergistically, usually by one competitively inhibiting beta-lactamase, thus protecting the other from inactivation. There are few reports on penicillins antagonizing each other. Eight strains of three genera (Proteus, Escherichia, Pseudomonas) isolated at Boston City Hospital or Institut Pasteur, Paris, showed antagonism of carbenicillin or am...
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although it has the advantage of being given orally, seems less effective, and ampicillin similarly. Comparative statistical evidence of the value of the various penicillins and of the antibiotics is not available, and would be difficult to obtain, but I have no personal doubt that at present in the acute infection methicillin and chloramphenical are the two most effective drugs. A major anxiet...
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Paper III (1) in this series describes several tests which were found to be useful in determining whether a given compound is utilized by the mold in penicillin formation. To provide proof of the incorporation of various acyl groups into the penicillin molecule and to be able to determine the chemical characteristics and biological properties of the various penicillins, isolation and crystalliz...
متن کاملThe Therapeutic Activity of Penicillins F, G, K, and X in Experimental Infections with Pneumococcus Type I and Streptococcus Pyogenes
1. The relative bactericidal activities of penicillins F, G, K, and X against Type I pneumococcus in vitro were 60, 100, 180, and 135. The corresponding activities against Streptococcus pyogenes, strain C-203, were 75, 100, 115, and 145, respectively. 2. The total curative doses (CD(50)) of penicillins F, G, K, and X in pneumococcal infections of white mice (ten injections at 3 hour intervals) ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1946
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4456.828